JOURNAL ARTICLE

Design, synthesis and evaluation of clioquinol–ebselen hybrids as multi-target-directed ligands against Alzheimer's disease

Zhiren WangWenrui LiYali WangXiruo LiLing HuangXingshu LiXingshu LiXingshu Li

Year: 2016 Journal:   RSC Advances Vol: 6 (9)Pages: 7139-7158   Publisher: Royal Society of Chemistry

Abstract

A novel series of compounds obtained by fusing the metal-chelating agent clioquinol and the antioxidant ebselen were designed, synthesized and evaluated as multi-target-directed ligands against Alzheimer's disease (AD).

Keywords:
Clioquinol Ebselen Chemistry Combinatorial chemistry Pharmacology Biochemistry Medicine Antioxidant

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27
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1.94
FWCI (Field Weighted Citation Impact)
52
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0.84
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Citation History

Topics

Organoselenium and organotellurium chemistry
Life Sciences →  Pharmacology, Toxicology and Pharmaceutics →  Toxicology
Cholinesterase and Neurodegenerative Diseases
Health Sciences →  Medicine →  Pharmacology
Free Radicals and Antioxidants
Physical Sciences →  Chemistry →  Organic Chemistry

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