Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

J Jerábek; Elisa Uliassi; Laura Guidotti; Jan Korábečný; Ondřej Soukup; Vendula Šepsová; Martina Hrabinová; Kamil Kuča; Manuela Bartolini; Emiliano Peña‐Altamira; Sabrina Petralla; Barbara Monti; Marinella Roberti; María Laura Bolognesi

doi:10.1016/j.ejmech.2016.12.048

JOURNAL ARTICLE

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

J Jerábek Elisa Uliassi Laura Guidotti Jan Korábečný Ondřej Soukup Vendula Šepsová Martina Hrabinová Kamil Kuča Manuela Bartolini Emiliano Peña‐Altamira Sabrina Petralla Barbara Monti Marinella Roberti María Laura Bolognesi

Year: 2016 Journal: European Journal of Medicinal Chemistry Vol: 127 Pages: 250-262 Publisher: Elsevier BV

DOI: 10.1016/j.ejmech.2016.12.048

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Keywords:

Tacrine Chemistry Acetylcholinesterase Resveratrol Drug discovery Cholinesterase Pharmacology Cytotoxicity Blood–brain barrier Alzheimer's disease Central nervous system In vitro Neuroscience Biochemistry Enzyme Disease Biology Internal medicine

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Cholinesterase and Neurodegenerative Diseases

Health Sciences → Medicine → Pharmacology

Computational Drug Discovery Methods

Physical Sciences → Computer Science → Computational Theory and Mathematics

Medicinal Plants and Neuroprotection

Health Sciences → Medicine → Complementary and alternative medicine

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Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

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