Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease

Mourad Chioua; Eleonora Buzzi; Ignacio Moraleda; Isabel Iriepa; Maciej Maj; Artur Wnorowski; Catia Giovannini; Anna Tramarin; Federica Portali; Lhassane Ismaïli; Pilar López‐Alvarado; María Laura Bolognesi; Krzysztof Jóźwiak; J. Carlos Menéndez; José Marco‐Contelles; Manuela Bartolini

doi:10.1016/j.ejmech.2018.06.044

JOURNAL ARTICLE

Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease

Mourad Chioua Eleonora Buzzi Ignacio Moraleda Isabel Iriepa Maciej Maj Artur Wnorowski Catia Giovannini Anna Tramarin Federica Portali Lhassane Ismaïli Pilar López‐Alvarado María Laura Bolognesi Krzysztof Jóźwiak J. Carlos Menéndez José Marco‐Contelles Manuela Bartolini

Year: 2018 Journal: European Journal of Medicinal Chemistry Vol: 155 Pages: 839-846 Publisher: Elsevier BV

DOI: 10.1016/j.ejmech.2018.06.044

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Keywords:

Tacrine Chemistry Nimodipine Pharmacology Calcium channel Cholinesterase Quinoline Stereochemistry Calcium Acetylcholinesterase Biochemistry Enzyme Medicine

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Cholinesterase and Neurodegenerative Diseases

Health Sciences → Medicine → Pharmacology

Computational Drug Discovery Methods

Physical Sciences → Computer Science → Computational Theory and Mathematics

Nicotinic Acetylcholine Receptors Study

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease

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