Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease

Xinnan Li; Tiantian Li; Pengfei Zhang; Xinuo Li; Li Lu; Yuan Sun; Bocheng Zhang; Stephanie Allen; Lisa J. White; James B. Phillips; Zheying Zhu; Hequan Yao; Jinyi Xu

doi:10.1016/j.ejmech.2022.114841

JOURNAL ARTICLE

Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease

Xinnan Li Tiantian Li Pengfei Zhang Xinuo Li Li Lu Yuan Sun Bocheng Zhang Stephanie Allen Lisa J. White James B. Phillips Zheying Zhu Hequan Yao Jinyi Xu

Year: 2022 Journal: European Journal of Medicinal Chemistry Vol: 244 Pages: 114841-114841 Publisher: Elsevier BV

DOI: 10.1016/j.ejmech.2022.114841

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Keywords:

Chemistry Clioquinol Acetylcholinesterase Tacrine Neuroprotection Pharmacology Aché In vivo Lead compound Donepezil Inhibitory postsynaptic potential IC50 Rivastigmine Cholinesterase Biochemistry In vitro Neuroscience Dementia Enzyme Internal medicine Disease Medicine Biology

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Cholinesterase and Neurodegenerative Diseases

Health Sciences → Medicine → Pharmacology

Alzheimer's disease research and treatments

Health Sciences → Medicine → Physiology

Computational Drug Discovery Methods

Physical Sciences → Computer Science → Computational Theory and Mathematics

Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease

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