JOURNAL ARTICLE

Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease

Wei XuXiaobing WangZhimin WangJia‐Jia WuFan LiJin WangLing-Yi Kong

Year: 2016 Journal:   MedChemComm Vol: 7 (5)Pages: 990-998   Publisher: Royal Society of Chemistry

Abstract

A novel family of donepezil–ferulic acid hybrids were designed, synthesized and biologically evaluated as multi-target-directed ligands against Alzheimer's disease by fusing a fragment of donepezil and ferulic acid.

Keywords:
Donepezil Ferulic acid Hybrid Chemistry Disease Pharmacology Biochemistry Combinatorial chemistry Biology Medicine Botany Internal medicine Dementia

Metrics

57
Cited By
6.46
FWCI (Field Weighted Citation Impact)
50
Refs
0.97
Citation Normalized Percentile
Is in top 1%
Is in top 10%

Citation History

Topics

Cholinesterase and Neurodegenerative Diseases
Health Sciences →  Medicine →  Pharmacology
Medicinal Plants and Neuroprotection
Health Sciences →  Medicine →  Complementary and alternative medicine
Synthesis of Indole Derivatives
Physical Sciences →  Chemistry →  Organic Chemistry

Related Documents

© 2026 ScienceGate Book Chapters — All rights reserved.