Scalable Electrochemical Dehydrogenative Lactonization\nof C(sp²/sp³)–H Bonds

Abstract

A practical, electrochemical\nmethod is developed for the direct\ndehydrogenative lactonization of C­(sp²/sp³)–H\nbonds under external oxidant- and metal-free conditions, delivering\ndiverse lactones, including coumarin derivatives with excellent regioselectivity.\nThe scalable nature of this newly developed electrochemical process\nwas demonstrated on a 40 g scale following an operationally simple\nprotocol. The remote lactonization of C­(sp³)–H bonds\nwould constitute an important synthetic advance toward electrochemical\nC–O bond formation.