Ligand-Promoted\nAlkylation of C(sp³)–H\nand C(sp²)–H Bonds

Abstract

9-Methylacridine\nwas identified as a generally effective ligand\nto promote a Pd­(II)-catalyzed C­(sp³)–H and C­(sp²)–H alkylation of simple amides with various alkyl\niodides. This alkylation reaction was applied to the preparation of\nunnatural amino acids and geometrically controlled tri- and tetrasubstituted\nacrylic acids.