Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reaction\nbetween Unactivated C(sp²)–H and C(sp³)–H Bonds

Abstract

Catalytic oxidative\ncross-dehydrogenative coupling between unactivated\nC­(sp²)–H and C­(sp³)–H bonds is\nachieved by the cobalt-catalyzed <i>o</i>-alkylation reaction\nof aromatic carboxamides containing (pyridin-2-yl)­isopropyl amine\n(PIP–NH₂) as a <i>N</i>,<i>N</i>-bidentate directing group. Many different C­(sp³)–H\nbonds in alkanes, toluene derivatives and even in the α-position\nof ethers and thioethers can be used as coupling partners. This method\nhas a broad substrate scope and the tolerance of various functional\ngroups.