Catalytic Allylic Alkylation via the Cross-Dehydrogenative-Coupling Reaction\nbetween Allylic sp³ C−H and Methylenic sp³ C−H Bonds

Abstract

A catalytic allylic alkylation was developed via the cross-dehydrogenative-coupling reaction of allylic sp³ C−H and methylenic sp³ C−H catalyzed by copper bromide and cobalt chloride in the presence of an oxidizing reagent, <i>t</i>-BuOOH. This methodology provides a direct way to use allylic sp³ C−H bonds for forming C−C bonds.