Synthesis of New Maleopimaric Acid Derivatives Contaning Thiazole Fragments

Abstract

The condensation of maleopimaric acid or its chloride with 2-aminothiazole or 2-aminobenzothiazole afforded new maleopimaric acid imides and amides containing thiazole or benzothiazole fragments. Maleo­pimaric acid chloride reacted with 2-aminothiazole at room in anhydrous methylene chloride at room tempera­ture to give a mixture of the corresponding N-thiazolyl amide and a maleopimaric acid derivative containing a thiazole ring in both carboxylic acid and anhydride moieties at a ratio of 7:2.