JOURNAL ARTICLE
Cu-Catalyzed Site-Selective and Enantioselective Ring Opening of Cyclic Diaryliodoniums with 1,2,3-Triazoles
Zengyin ChaoMingming MaZhenhua Gu
Year: 2020 Journal: Organic Letters Vol: 22 (16)Pages: 6441-6446 Publisher: American Chemical Society
Abstract
A Cu-catalyzed enantioselective ring-opening/triazolylation reaction is reported. The reaction shows excellent chemoselectivity regarding the three different nitrogen atoms of 1,2,3-triazoles. The optically enriched axially chiral aryl iodides thus obtained were readily derivatized to different types of chiral phosphine ligands and their corresponding copper or palladium complexes.
Keywords:
Enantioselective synthesis Chemistry Chemoselectivity Phosphine Ring (chemistry) Catalysis Aryl Palladium Combinatorial chemistry Copper Optically active Stereochemistry Medicinal chemistry Organic chemistry Alkyl
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86
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0.91
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Citation History
Topics
Axial and Atropisomeric Chirality Synthesis
Physical Sciences → Chemistry → Organic Chemistry
Molecular spectroscopy and chirality
Physical Sciences → Chemistry → Spectroscopy
Alkaloids: synthesis and pharmacology
Life Sciences → Pharmacology, Toxicology and Pharmaceutics → Pharmacology
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