Cu-Catalyzed Enantioselective Atropisomer Synthesis\nvia Thiolative Ring Opening of Five-Membered Cyclic Diaryliodoniums
Mengqing Hou (4249309)Ruixian Deng (1829407)Zhenhua Gu (469659)
Abstract
A Cu-catalyzed asymmetric thiolative\nring opening reaction of five-membered\ndiaryliodonium salts and potassium thioates for the synthesis of atropisomeric\n2′-iodo-[1,1′-biphenyl]-2-yl thioates was realized.\nThe optimal catalytic system, Cu(CH<sub>3</sub>CN)<sub>4</sub>PF<sub>6</sub>/(Ph)-bis(oxazoline), showed the best performance with respect\nto both yields and stereocontrol. Finally, the utility of these products\nwas briefly demonstrated by the synthesis of an axially chiral <i>P,S</i>-ligand.
Metrics
Topics
Related Documents
Cu-Catalyzed Enantioselective Atropisomer Synthesis via Thiolative Ring Opening of Five-Membered Cyclic Diaryliodoniums
Mengqing HouRuixian DengZhenhua Gu
Cu-Catalyzed Enantioselective Ring Opening of Cyclic Diaryliodoniums toward the Synthesis of Chiral Diarylmethanes
Bin LiZengyin ChaoChunyu LiZhenhua Gu
Cu-Catalyzed Site-Selective and Enantioselective Ring Opening of Cyclic Diaryliodoniums with 1,2,3-Triazoles
Zengyin ChaoMingming MaZhenhua Gu
Enantioselective Synthesis of 3-Iodo-4-arylcoumarinyl Atropisomers via Cu-Catalyzed Asymmetric Ring-Opening of Cyclic Hetero Diaryliodoniums
Xiaojie SunHan YangGuangwei WangZhenhua Gu
Copper-Catalyzed Enantioselective Ring-Opening of Cyclic Diaryliodoniums and O-Alkylhydroxylamines
Qigang LiMingkai ZhangShuming ZhanZhenhua Gu