MOF-Derived\nPorous Ni₂P/Graphene Composites\nwith Enhanced Electrochemical Properties for Sensitive Nonenzymatic\nGlucose Sensing

Abstract

Herein,\nwe report a high-performance electrocatalyst by orientationally\ngrowing Ni₂P nanoparticles in situ on graphene film (Ni₂P/G) for nonenzymatic glucose sensors in alkaline media. The\ncombination of highly active Ni₂P and stable graphene film\nwith rapid conductivity enables this composite to display excellent\nelectrochemical activity toward glucose with enhanced electron transfer\nrate and steadiness. With Ni-MOF-74 as a precursor, Ni₂P/G showed even metal distribution, massive exposure of active sites,\nand spatially ordered structure. Benefiting from the synergistic reaction\nof Ni₂P particles and graphene, this metal–organic\nframeworks (MOF)-derived composite exhibited high electrocatalytic\nactivity and specificity toward glucose electrooxidation. Under optimized\nconditions, a wide linear response was obtained from 5 μM to\n1.4 mM with a detection limit of 0.44 μM. Furthermore, an excellent\nlinear response (<i>R</i>² = 0.9897) was also\nobtained by a Ni₂P/G modified electrode in human serum\nwith the concentration of glucose ranging from 1 to 8 mM, indicating\nthat the Ni₂P/G platform could be utilized for glucose\nmonitoring in practical life.