Paper Capillary Enables Effective Sampling for Microfluidic\nPaper Analytical Devices

Abstract

The paper capillary is introduced\nto enable effective sampling\non microfluidic paper analytical devices. By coupling the macroscale\ncapillary force of paper capillary and the microscale capillary forces\nof native paper, fluid transport can be flexibly tailored with proper\ndesign. Subsequently, a hybrid-fluid-mode paper capillary device was\nproposed which enables fast and reliable sampling in an arrayed form\nwith less surface adsorption and bias for different components. The\nresulting device thus supports high-throughput, quantitative, and\nrepeatable assays by manual operation. With all these merits, multiplex\nanalysis of ions, proteins, and microbes have all been realized on\nthis platform, which has paved the way to higher analysis on μPADs.