Formulation And Evaluation of Wound Healing Cream Containing Tectona Grandis Extract

Abstract

The formulation and characterization of a wound healing cream containing Tectona grandis (teak) leaf extract was investigated to evaluate its potential therapeutic effects. Tectona grandis, a plant traditionally known for its medicinal properties, has been reported to possess antiinflammatory, antioxidant, and antimicrobial activities, making it a promising candidate for wound care. In this study, an ointment base was prepared using common excipients, and the extract of Tectona grandis was incorporated into the cream in varying concentrations. The physicochemical properties of the formulated cream, including pH, spread ability, consistency, and stability, were evaluated to ensure its suitability for topical application. Additionally, in vitro antimicrobial tests and skin irritation studies were conducted to assess the safety and efficacy of the cream. The wound healing potential was further assessed using standard animal models, which showed a significant improvement in wound closure and tissue regeneration. The results indicated that the wound healing cream containing Tectona grandis extract could enhance the healing process and could be a promising alternative for treating skin wounds and ulcers. Further studies are recommended to explore the molecular mechanisms underlying the observed therapeutic effects.