Palladium-Catalyzed Decarbonylative Heck Coupling\nof Aromatic Carboxylic Acids with Terminal Alkenes

Abstract

A palladium-catalyzed\ndecarbonylative alkenylation of aromatic\ncarboxylic acids was developed. Under the reaction conditions, various\nbenzoic acids including those bearing functional groups coupled to\nterminal alkenes, producing the corresponding internal alkenes in\ngood to high yields. Cinnamic acids and bioactive benzoic acids such\nas 3-methylflavone-8-carboxylic acid, probenecid, adapalin, and febuxostat\nwere also applicable to this reaction, demonstrating the potential\nsynthetic value of this new reaction in organic synthesis.