Reversible enzyme-catalysed NAD<sup>+</sup>/NADH electrochemistry

Peter D. Giang; Dimitri Niks; Sheron Hakopian; Russ Hille; Paul V. Bernhardt

doi:10.1039/d5sc00570a

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Reversible enzyme-catalysed NAD⁺/NADH electrochemistry

Peter D. Giang Dimitri Niks Sheron Hakopian Russ Hille Paul V. Bernhardt

Year: 2025 Journal: Chemical Science Vol: 16 (14)Pages: 6035-6049 Publisher: Royal Society of Chemistry

DOI: 10.1039/d5sc00570a

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Abstract

The formate dehydrogenase subcomplex FdsBG from Cupriavidus necator has been electrochemically activated to reversibly interconvert NAD + /NADH and provide unique insight to its kinetics and reactivity.

Keywords:

NAD+ kinase Electrochemistry Enzyme Chemistry Biochemistry Combinatorial chemistry Electrode Physical chemistry

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Electrochemical sensors and biosensors

Physical Sciences → Engineering → Electrical and Electronic Engineering

Advanced biosensing and bioanalysis techniques

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

CO2 Reduction Techniques and Catalysts

Physical Sciences → Energy → Renewable Energy, Sustainability and the Environment

Reversible enzyme-catalysed NAD⁺/NADH electrochemistry

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