Development of human lactate dehydrogenase a inhibitors: high-throughput screening, molecular dynamics simulation and enzyme activity assay

Yuanyuan Shu; Jianda Yue; Yaqi Li; Yekui Yin; Jiaxu Wang; Tingting Li; Xiao He; Songping Liang; Gaihua Zhang; Zhonghua Liu; Ying Wang

doi:10.1007/s10822-024-00568-y

JOURNAL ARTICLE

Development of human lactate dehydrogenase a inhibitors: high-throughput screening, molecular dynamics simulation and enzyme activity assay

Yuanyuan Shu Jianda Yue Yaqi Li Yekui Yin Jiaxu Wang Tingting Li Xiao He Songping Liang Gaihua Zhang Zhonghua Liu Ying Wang

Year: 2024 Journal: Journal of Computer-Aided Molecular Design Vol: 38 (1)Pages: 28-28 Publisher: Springer Science+Business Media

DOI: 10.1007/s10822-024-00568-y

Get Full-Text PDF Get Analytical Report

Keywords:

Lactate dehydrogenase A Virtual screening Lactate dehydrogenase Enzyme Biochemistry Lactic acid High-throughput screening Dehydrogenase Docking (animal) Chemistry Computational biology Biology Drug discovery Bacteria Genetics

Metrics

Cited By

2.84

FWCI (Field Weighted Citation Impact)

Refs

0.85

Citation Normalized Percentile

Is in top 1%

Is in top 10%

Citation History

Topics

Cancer, Hypoxia, and Metabolism

Life Sciences → Biochemistry, Genetics and Molecular Biology → Cancer Research

Protein Structure and Dynamics

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Computational Drug Discovery Methods

Physical Sciences → Computer Science → Computational Theory and Mathematics

Development of human lactate dehydrogenase a inhibitors: high-throughput screening, molecular dynamics simulation and enzyme activity assay

Metrics

Citation History

Topics

Related Documents

Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations

Human Lactate Dehydrogenase A Inhibitors: A Molecular Dynamics Investigation

Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation

A high throughput screening assay for human Thyroperoxidase inhibitors

Colorimetric, High-Throughput Assay for Screening Angiotensin I-Converting Enzyme Inhibitors