Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation

Sichuan Xiang; Ding Huang; Qiaolin He; Jie Li; Kin Yip Tam; Shaolin Zhang; Yun He

doi:10.7270/q2n87ff4

ScienceGate Book Chapters

JOURNAL ARTICLE

Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation

Sichuan Xiang Ding Huang Qiaolin He Jie Li Kin Yip Tam Shaolin Zhang Yun He

Year: 2020 Journal: European Journal of Medicinal Chemistry Vol: 203 Pages: 112579-112579 Publisher: Elsevier BV

DOI: 10.7270/q2n87ff4

Get Full-Text PDF Get Analytical Report

Keywords:

Lactate dehydrogenase A Glycolysis Lactate dehydrogenase Chemistry Biochemistry Kinase Pyruvate dehydrogenase complex Citric acid cycle Virtual screening Dehydrogenase Cancer cell Pyruvate kinase High-throughput screening Enzyme Drug discovery Cancer Biology

Metrics

Cited By

0.96

FWCI (Field Weighted Citation Impact)

Refs

0.66

Citation Normalized Percentile

Is in top 1%

Is in top 10%

Citation History

Topics

Cancer, Hypoxia, and Metabolism

Life Sciences → Biochemistry, Genetics and Molecular Biology → Cancer Research

ATP Synthase and ATPases Research

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Metabolism, Diabetes, and Cancer

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation

Metrics

Citation History

Topics

Related Documents

Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations

High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity

Development of human lactate dehydrogenase a inhibitors: high-throughput screening, molecular dynamics simulation and enzyme activity assay

Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment

Targeting the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis to discover potent PDK inhibitors through structure-based virtual screening and pharmacological evaluation