JOURNAL ARTICLE

Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation

Sichuan XiangDing HuangQiaolin HeJie LiKin Yip TamShaolin ZhangYun He

Year: 2020 Journal:   European Journal of Medicinal Chemistry Vol: 203 Pages: 112579-112579   Publisher: Elsevier BV
Keywords:
Lactate dehydrogenase A Glycolysis Lactate dehydrogenase Chemistry Biochemistry Kinase Pyruvate dehydrogenase complex Citric acid cycle Virtual screening Dehydrogenase Cancer cell Pyruvate kinase High-throughput screening Enzyme Drug discovery Cancer Biology

Metrics

23
Cited By
0.96
FWCI (Field Weighted Citation Impact)
26
Refs
0.66
Citation Normalized Percentile
Is in top 1%
Is in top 10%

Citation History

Topics

Cancer, Hypoxia, and Metabolism
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Cancer Research
ATP Synthase and ATPases Research
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Molecular Biology
Metabolism, Diabetes, and Cancer
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Molecular Biology

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