Constructing triazole-modified quinazoline derivatives as selective c-MYC G-quadruplex ligands and potent anticancer agents through click chemistry

Jiong-Heng Cai; Dan-Yan Yang; Junjie Zhang; Jia‐Heng Tan; Zhi‐Shu Huang; Shuo‐Bin Chen

doi:10.1016/j.bioorg.2024.107173

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Constructing triazole-modified quinazoline derivatives as selective c-MYC G-quadruplex ligands and potent anticancer agents through click chemistry

Jiong-Heng Cai Dan-Yan Yang Junjie Zhang Jia‐Heng Tan Zhi‐Shu Huang Shuo‐Bin Chen

Year: 2024 Journal: Bioorganic Chemistry Vol: 144 Pages: 107173-107173 Publisher: Elsevier BV

DOI: 10.1016/j.bioorg.2024.107173

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Keywords:

Chemistry Quinazoline Transcription factor Transcription (linguistics) G-quadruplex Triazole Click chemistry Cancer research Carcinogenesis Small molecule Stereochemistry Cell biology Combinatorial chemistry Biochemistry Gene Biology DNA

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DNA and Nucleic Acid Chemistry

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

RNA Interference and Gene Delivery

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Advanced biosensing and bioanalysis techniques

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Constructing triazole-modified quinazoline derivatives as selective c-MYC G-quadruplex ligands and potent anticancer agents through click chemistry

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