Selective recognition of c-MYC G-quadruplex DNA using prolinamide derivatives

Ajay Kumar Chauhan; Sushovan Paladhi; Manish Debnath; Jyotirmayee Dash

doi:10.1039/c6ob00177g

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Selective recognition of c-MYC G-quadruplex DNA using prolinamide derivatives

Ajay Kumar Chauhan Sushovan Paladhi Manish Debnath Jyotirmayee Dash

Year: 2016 Journal: Organic & Biomolecular Chemistry Vol: 14 (24)Pages: 5761-5767 Publisher: Royal Society of Chemistry

DOI: 10.1039/c6ob00177g

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Abstract

Herein we report the design, synthesis, biophysical and biological evaluation of triazole containing prolinamide derivatives as selectivec-MYCG-quadruplex binding ligands.

Keywords:

Chemistry DNA G-quadruplex Combinatorial chemistry Computational biology Stereochemistry Biochemistry

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DNA and Nucleic Acid Chemistry

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Advanced biosensing and bioanalysis techniques

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

RNA Interference and Gene Delivery

Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Selective recognition of c-MYC G-quadruplex DNA using prolinamide derivatives

Abstract

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