CAR-T Therapy in Treating Solid Tumor: Application and Limitations

Abstract

CAR-T therapy has emerged as a revolutionary approach in the battle against cancer. By leveraging the body's own immune system, this technique harnesses the power of T cells, which are genetically engineered to recognize specific antigens found on cancer cells. The procedure involves isolating lymphocytes from patients, followed by laboratory-based genetic modifications to infuse them with distinct CAR genes. Once these enhanced CAR-T cells are reintroduced into the patient, they actively target and neutralize cancer cells. However, the journey of CAR-T therapy is not without challenges. The selection of the right antigen is paramount, as an incorrect choice can lead to unintended consequences. Moreover, the application of this therapy in solid tumors presents its own set of complexities. This review aims to shed light on the clinical potential of CAR-T therapy, the obstacles faced in the realm of solid tumor treatment, and the ongoing research endeavors to refine and improve this promising therapeutic strategy.