Voltammetric Determination of N-Actylcysteine Using Modified Multiwall Carbon Nanotubes Paste Electrode

Abstract

A ferrocene modified carbon nanotubes paste electrode (FCMCNTPE) was constructed and used as a fast and sensitive tool for the determination of N-acetylcysteine (NAC) at trace level. It has been shown by direct current cyclic voltammetry and double step chronoamperometry that this sensor can catalyze the oxidation of NAC in phosphate buffer solution (PBS) and produces a sharp oxidation peak current. Linear calibration ranges were 1.0-400.0 µmol L-1 with detections limit of 0.6 µmol L-1 for differential pulse voltammetry. Finally, the sensor was also examined as a selective, simple and precise new electrochemical sensor for the determination of NAC in real samples such as drug, serum and urine.