Voltammetric Determination of Nimesulide Using Multiwalled Carbon Nanotubes Modified Carbon Paste Electrode

Abstract

A multiwalled carbon nanotubes (MWCNTs) modified carbon paste electrode (CPE) was prepared for voltammetric determination of antiinflammatory drug nimesulide (NIM).The electro-oxidation of NIM was exhibited irreversible and diffusion controlled process with MWCNTs modified CPE.The linear response between peak current and concentration in the quantitative determination of NIM by differential pulse voltammetry in 0.1 M phosphate buffer solution (PBS) at pH 5.0 obtained in the range of the concentration from 6×10 -8 -1×10 -5 M with limit of detection (LOD) 1.07×10 -9 M and limit of quantification (LOQ) 3.24×10 -9 M. Differential pulse voltammetry was developed according to linear response of NIM with high selectivity, precision, accuracy using modified electrode was successfully applied to the determination of NIM in pharmaceuticals and human serum samples.