The promotion of cross-cultural management work can provide strong support for the high-level promotion of international business activities of enterprises. The article first summarizes the main roles and impacts of cross-cultural management in international business activities of enterprises, believing that cross-cultural management plays a role in the cultural differences between East and West in terms of personal relationships, cooperative norms, time awareness, and cultural conflicts, propose cross-cultural management strategies in international business activities of enterprises, by strengthening cultural construction, optimizing negotiation methods, adjusting strategic decisions, and adjusting market choices, to ensure the high-level operation of cross-cultural management related work.