MOF-based Electrochemical Sensors for Neurochemicals

Abstract

The detection and quantification of neurochemicals under physiological conditions is vital for monitoring their levels from human body fluids. These chemicals are significant due to their role in human physiology which includes metabolic, mental, and nutritional health. Deficiency in neurochemicals (NCs) such as hypoxanthine (HXA), xanthine (XA), epinephrine (EP), acetylcholine(Ach), norepinephrine (NE), dopamine (DA) can cause various central nervous system (CNS) disorders. MOFs are porous materials constructed by using inorganic metal ion precursors and organic linker molecules. Due to their topology, very large surface area, and tunable porosity they are highly promising substrate materials for various applications. Electrochemical sensors are fabricated from metal-organic frameworks and their composite materials are emerging as efficient tools to monitor NCs at trace level. This chapter describes various aspects of the synthesis of MOF-based biomarkers and their fabrication as electrochemical sensors in the quantification of neurochemicals.