Abstract

We develop a high speed compressive Raman imaging technology using a programmable binary spectral filter and a single channel detector to perform fast Raman detection and concentration estimation of know species over millimeters field of view. The technology is x100 times faster than commercial CCD based systems and x10 times faster than the EMCCD based systems. We report fast imaging of breast micro-calcifications, SERS particles, pharmaceutical tablets and micro-plastics. We also present a novel fast line scan compressive Raman imaging technique using spatial frequency-modulated illumination (SPIFI) that enables to encode space into the frequency domain to acquire single shot line images. We demonstrate the imaging and classification of three different chemical species at line scan rates of 40 Hz.

Keywords:
Raman spectroscopy Detector Materials science Compressed sensing Optics Line (geometry) Filter (signal processing) Image resolution Medical imaging Computer science Artificial intelligence Physics Computer vision

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Topics

Spectroscopy Techniques in Biomedical and Chemical Research
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Biophysics
Photoacoustic and Ultrasonic Imaging
Physical Sciences →  Engineering →  Biomedical Engineering
Optical Coherence Tomography Applications
Physical Sciences →  Engineering →  Biomedical Engineering
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