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JOURNAL ARTICLE

<p>Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles</p>

Catarina Roma‐RodriguesAlexandra R. FernandesPedro V. Baptista

Year: 2019 Journal:   International Journal of Nanomedicine Vol: Volume 14 Pages: 6843-6854   Publisher: Dove Medical Press
DOI: 10.2147/ijn.s215711
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Abstract

Exosomes derived from blast cells are capable to trigger (neo)-angiogenesis, a key factor for the progression and spreading of cancer, in particular in CML. AuNPs functionalized with specific antiangiogenic peptides are capable to block the effect of the exosomes produced by malignant cells via modulation of the intrinsic VEGFR pathway. Together, these data highlight the potential of nanomedicine-based strategies against cancer proliferation.

Keywords:
Colloidal gold Microvesicles Cancer research Leukemia Medicine Pharmacology Nanoparticle Nanotechnology Chemistry Materials science Internal medicine microRNA Biochemistry

Metrics

28
Cited By
1.65
FWCI (Field Weighted Citation Impact)
40
Refs
0.81
Citation Normalized Percentile
Is in top 1%
Is in top 10%

Citation History

Topics

Extracellular vesicles in disease
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Molecular Biology
MicroRNA in disease regulation
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Cancer Research
Circular RNAs in diseases
Life Sciences →  Biochemistry, Genetics and Molecular Biology →  Molecular Biology

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