The Synthesis of RNA Containing the Modified NucleotidesN2-Methylguanosine andN6,N6-Dimethyladenosine

Jason P. Rife; Charles S. Cheng; Peter B. Moore; Scott A. Strobel

doi:10.1080/07328319808004317

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The Synthesis of RNA Containing the Modified NucleotidesN²-Methylguanosine andN⁶,N⁶-Dimethyladenosine

Jason P. Rife Charles S. Cheng Peter B. Moore Scott A. Strobel

Year: 1998 Journal: Nucleosides and Nucleotides Vol: 17 (12)Pages: 2281-2288 Publisher: Taylor & Francis

DOI: 10.1080/07328319808004317

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Abstract

Abstract Abstract The phosphoramidites of the naturally occurring modified nucleotides N 2-methylguanosine and N 6,N 6-dimethyladenosine were synthesized and incorporated into short oligoribonucleotides. Described are the syntheses of the phosphoramidites and the procedures used to deprotect oligoribonucleotides in which the O 6 of m2G is protected with a 2-(p-nitrophenyl)ethyl group.

Keywords:

Nucleotide RNA Chemistry Stereochemistry Biochemistry Gene

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The Synthesis of RNA Containing the Modified NucleotidesN²-Methylguanosine andN⁶,N⁶-Dimethyladenosine

Abstract

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