Synthesis of functionalized magnetic nanoparticles as a nanocarrier for targeted drug delivery

Abstract

Abstract In this research, iron oxide magnetic nanoparticles (NPs) were synthesized by chemical co‐precipitation method. The surface of particles was grafted with β‐cyclodextrin/ N , N ‐dimethylacrylamide (β‐ CD / DMAA ) copolymer. Potency of NPs as carrier of antibiotic ofloxacin ( OFL ) was evaluated. They were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, elemental analysis, and thermogravimetric analysis. The effect of the adsorption parameters such as pH , contact time, and temperature for sorption of drug onto NPs was evaluated and optimized. The drug release profile showed that approximately 60% of the adsorbed drug was released in the first 10 min at pH of 1.2 (simulated gastric fluid) and 55% was released within 30 hr in pH of 7.4 (simulated intestinal fluid). Findings of study suggested the suitability of β‐ CD / DMAA grafted magnetic NPs for OFL delivery.