JOURNAL ARTICLE

Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer’s disease based on the fusion of donepezil and curcumin

Jun YanJinhui HuAnqiu LiuLin HeXingshu LiHui Wei

Year: 2017 Journal:   Bioorganic & Medicinal Chemistry Vol: 25 (12)Pages: 2946-2955   Publisher: Elsevier BV
Keywords:
Chemistry Curcumin Acetylcholinesterase Donepezil IC50 Aché Antioxidant Stereochemistry Alzheimer's disease Lead compound Docking (animal) Selectivity Pharmacology In vitro Combinatorial chemistry Biochemistry Enzyme Disease Internal medicine

Metrics

63
Cited By
6.70
FWCI (Field Weighted Citation Impact)
27
Refs
0.97
Citation Normalized Percentile
Is in top 1%
Is in top 10%

Citation History

Topics

Cholinesterase and Neurodegenerative Diseases
Health Sciences →  Medicine →  Pharmacology
Alzheimer's disease research and treatments
Health Sciences →  Medicine →  Physiology
Medicinal Plants and Neuroprotection
Health Sciences →  Medicine →  Complementary and alternative medicine

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