Synthesis of L-Ascorbic Acid

Abstract

The methods by which L-ascorbic acid has been synthesized are readily divided into three major categories. The first involves coupling a C1 fragment and a C5 fragment, and the second involves coupling a C2 fragment and a C4 fragment. The third involves the conversion of a C6 chain into the correct oxidation state and stereochemical configuration. All of these approaches will be reviewed with special regard given to those syntheses that are suitable for the preparation of analogues of L-ascorbic acid, the preparation of radiolabeled derivatives of L-ascorbic acid, and the current commercial synthesis of L-ascorbic acid.