LABORATORY STUDY OF COLLAGEN WOUND DRESSING (CAS)

Abstract

ABSTRACT In order to determine whether collagen wound dressing (CAS) has any immunogenicity, we carried out various immunological tests with Japanese albino rabbits and BALB/c mice. CAS extract produced no antibodies while atelocollagen, the source material of CAS, has less antigenicity than acid soluble collagen, a tropocollagen. Moreover, the antigenicity of CAS was much lower than that of lyophilized porcine skin which is much used in clinical practice. It is assumed that CAS would be immunologically safe as a wound dressing.