JOURNAL ARTICLE

TERATOLOGICAL STUDIES ON COLLAGEN WOUND DRESSING (CAS) IN MICE

Ueto TAKADAM MoriguchiToshiaki HataAtsuko Yamamoto

Year: 1982 Journal:   The Journal of Toxicological Sciences Vol: 7 (SupplementII)Pages: 57-61   Publisher: Japanese Society of Toxicological Sciences

Abstract

We subcutaneously injected collagen wound dressing (CAS) extracts equivalent to the area covering human body surface by 35 and 70%, respectively, into mouse dams from days 6 to 15 of pregnancy. No toxicity was observed in dams and no external, skeletal and visceral anomalies related to CAS treatment were observed in fetuses. It is, therefore, concluded that CAS extracts produces no teratogenesis after subcutaneous injection during organogenesis in mice.

Keywords:
Organogenesis Fetus Teratology Subcutaneous injection Pregnancy Toxicity Medicine Wound dressing Developmental toxicity Anatomy Surgery Pathology Chemistry Internal medicine Biology Biochemistry Materials science

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Topics

Wound Healing and Treatments
Health Sciences →  Medicine →  Rehabilitation
Surgical Sutures and Adhesives
Health Sciences →  Medicine →  Surgery
Reconstructive Surgery and Microvascular Techniques
Health Sciences →  Medicine →  Surgery

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