Ueto TAKADAM MoriguchiToshiaki HataAtsuko Yamamoto
We subcutaneously injected collagen wound dressing (CAS) extracts equivalent to the area covering human body surface by 35 and 70%, respectively, into mouse dams from days 6 to 15 of pregnancy. No toxicity was observed in dams and no external, skeletal and visceral anomalies related to CAS treatment were observed in fetuses. It is, therefore, concluded that CAS extracts produces no teratogenesis after subcutaneous injection during organogenesis in mice.
Shinjiro MurataMasao FujigakiKoshiro UmemuraMasanori IzawaUichi ShibataTadahiko FujiiMasaru NishizawaKuniharu IwamotoKatsumi Matsumoto
Ueto TakedaMasanori IzawaT KoedaUichi Shibata
Ueto TakedaM OdakiMasayuki YokotaHitoshi SasakiT NiizatoH KawaotoTakeshi NabeTakashi ItoN IshiwatariH HayasakaM SekiT Koeda
Ueto TakedaMasanori IzawaT KoedaUichi Shibata