Synthesis of Some New 1,2,4‐Triazole Derivatives by <i>Mitsunobu</i> Chemistry

Abdolali Alizadeh

doi:10.1002/hlca.200590218

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Synthesis of Some New 1,2,4‐Triazole Derivatives by Mitsunobu Chemistry

Abdolali Alizadeh

Year: 2005 Journal: Helvetica Chimica Acta Vol: 88 (10)Pages: 2777-2780 Publisher: Wiley

DOI: 10.1002/hlca.200590218

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Abstract

Abstract The reactive 1 : 1 intermediate produced in the reaction between triphenylphosphine and diisopropyl azodicarboxylate has been trapped by isocyanates or isothiocyanates to yield 1,2,4‐triazole derivatives 2 ( Scheme 1 ). The structures of the highly functionalized compounds 2 were corroborated spectroscopically (IR, 1 H‐ and 13 C‐NMR, EI‐MS) and by elemental analyses. A mechanism for this type of cyclization is proposed ( Scheme 2 ).

Keywords:

Chemistry Mitsunobu reaction Triphenylphosphine Yield (engineering) 1,2,4-Triazole Triazole Combinatorial chemistry Organic chemistry Medicinal chemistry Computational chemistry Catalysis

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Synthesis and biological activity

Physical Sciences → Chemistry → Organic Chemistry

Synthesis and Characterization of Heterocyclic Compounds

Physical Sciences → Chemistry → Organic Chemistry

Synthesis and Biological Evaluation

Physical Sciences → Chemistry → Organic Chemistry

Synthesis of Some New 1,2,4‐Triazole Derivatives by Mitsunobu Chemistry

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