Fabrication and Characterization of Hydroxyapatite/Poly (L-Lactic Acid-Polycaprolactone Nanofibrous Composite Scaffolds

Abstract

The multistage aperture nanofibrous composite scaffolds were fabricated by frozen extraction combined with particle leaching from a PLLA/PCL/HA/dioxane/ ethanol ternary system. and then the morphology and biological activity of composite scaffolds were analyzed. Results show that adding the porogen is advantageous to the formation of multistage aperture nanofiber composite scaffolds. And HA adds more conducive to the deposit of CHA on composite scaffolds, raises the biologic activity of the composite scaffold.