Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer's disease

Long-Fei Pan; Xiaobing Wang; Sai‐Sai Xie; Suyi Li; Lingyi Kong

doi:10.1039/c3md00376k

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Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer's disease

Long-Fei Pan Xiaobing Wang Sai‐Sai Xie Suyi Li Lingyi Kong

Year: 2014 Journal: MedChemComm Vol: 5 (5)Pages: 609-616 Publisher: Royal Society of Chemistry

DOI: 10.1039/c3md00376k

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Abstract

Resveratrol derivatives were designed and synthesized as multitarget-directed agents for treating AD, and 6r was a balanced inhibitor toward all the tested targets.

Keywords:

Resveratrol Monoamine oxidase Monoamine oxidase B Chemistry Amyloid (mycology) Biochemistry Pharmacology Amyloid β Alzheimer's disease Monoamine neurotransmitter Disease Enzyme Biology Medicine Internal medicine Receptor Serotonin

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Cholinesterase and Neurodegenerative Diseases

Health Sciences → Medicine → Pharmacology

Computational Drug Discovery Methods

Physical Sciences → Computer Science → Computational Theory and Mathematics

Medicinal Plants and Neuroprotection

Health Sciences → Medicine → Complementary and alternative medicine

Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer's disease

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