Solubilization of griseofulvin by nonionic surfactants

Abstract

Abstract Four nonionic surfactants, Me[CH2]15·[OCH2·CH2]xOH where x = 10, 22, 45 and 60, and polyoxyethylene glycols 200, 400 and 1000 increased the solubility of griseofulvin over its value in water. Cetomacrogol micelles solubilize two molecules of griseofulvin per micelle. The site of solubilization seems likely to be the polyoxyethylene part of the micelles. The partial molal heats and entropies of solution decrease as surfactant or polyoxyethylene glycol concentration is increased.