2-(4-Methylpiperazin-1-yl)-4-phenyl-6-(thiophen-2-yl)-pyridine-3-carbonitrile

N. Mishriky; A. M. Moustafa

doi:10.3390/m794

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2-(4-Methylpiperazin-1-yl)-4-phenyl-6-(thiophen-2-yl)-pyridine-3-carbonitrile

N. Mishriky A. M. Moustafa

Year: 2013 Journal: Molbank Vol: 2013 (1)Pages: M794-M794 Publisher: Multidisciplinary Digital Publishing Institute

DOI: 10.3390/m794

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Abstract

2-(4-Methylpiperazin-1-yl)-4-phenyl-6-(thiophen-2-yl)-pyridine-3-carbonitrile (4) was synthesized via nucleophilic substitution reaction of 1-methylpiperazine with 2-bromo analogue 3. The latter was obtained through bromination (Br2/AcOH) of 2-[3-oxo-1-phenyl-3-(thiophen-2-yl)propyl]malononitrile (2).

Keywords:

Malononitrile Chemistry Pyridine Nucleophilic substitution Halogenation Medicinal chemistry Organic chemistry Catalysis

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Synthesis of heterocyclic compounds

Physical Sciences → Chemistry → Organic Chemistry

Synthesis and Reactivity of Heterocycles

Physical Sciences → Chemistry → Organic Chemistry

Synthesis and biological activity

Physical Sciences → Chemistry → Organic Chemistry

2-(4-Methylpiperazin-1-yl)-4-phenyl-6-(thiophen-2-yl)-pyridine-3-carbonitrile

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