Electrochemical Reduction and Voltammetric Determination of Metronidazole Benzoate at Modified Carbon Paste Electrode

Abstract

A metalloporphyrin incorporated carbon paste sensor has been developed\nfor the determination of metronidazole benzoate (MTZB). Zn(II) complex\nof 5,10,15,20-tetrakis (3-methoxy-4-hydroxy phenyl) porphyrin (TMHPP) was\nused as the active material. The MTZB gave a well-defined reduction peak at\n- 0.713V in 0.1 mol l -1 phosphate buffer solution of pH around 7. Compared\nwith bare carbon paste electrode (CPE), the TMHPP Zn(II) modified electrode\nsignificantly enhanced the reduction peak current of MTZB as well as lowered\nits reduction potential. Under optimum conditions the reduction peak current\nwas proportional to MTZB concentration over the range 1×10-3 mol1-1 to 1×10-5mol1-1. The detection limit was found to be 4.36×10-6mol1-1\n. This\nsensor has been successfully applied for the determination of MTZB in pharmaceutical\nformulations and urine samples.