Solvent-free Zinc-catalyzed Amine N-Formylation

Abstract

C for 2 h (entry 1). Among the various metals examined for this transformation, zinc was found to be the most effective in terms of chemical yield and reaction time (entries 2-4). Activated zinc was observ-ed to be even more effective, affording 97% of the desired pro-duct in 30 min (entry 5). With a stoichiometric amount of zinc, the reaction showed very similar efficiency to the catalytic vari-ant of the reaction (entry 6). A decrease in the amount of formic acid produced a lower yield of the desired product (entry 7).Increasing the reaction temperature up to 100