P2.2.10 Development of Guided SH-SAW based Wireless Sensing Platform for Monitoring Protein Binding

Abstract

In this study, a wireless biosensing platform was developed for the detection of protein binding. The system consists of a layered ZnO/36° YX-LiTaO3 SH-SAW device and a microfluidic flow cell. The influence of the interactions between protein A and mouse IgG on the characteristics of the SH-SAW device was measured and analyzed for varying concentrations of mouse IgG. The experimental results demonstrated that the insertion loss of the device increased from -46.8 dB to -50.9 dB and the center frequency of the device decreased from 94.56 MHz to 94.49 MHz as the mouse IgG concentration was increased from 1 µM to 40 µM, respectively. This sensor platform enabled real time monitoring of protein binding within a microfluidic flow cell.