Differential pulse anoding voltammetric determination of torasemide using carbon paste electrode

Abstract

Torasemide electrochemical behavior at a carbon paste electrode was investigated and optimized using cyclic and differential pulse voltammetry in 0.04 mol/L Britton-Robinson (BR) buffer pH 2.8. Cyclic voltammetry showed that the oxidation process was irreversible and primarily controlled by diffusion. The responses of differential pulse were linear over the torasemide concentration range of 0.35–4.13 µg/mL, with detection and quantification limits of 0.110 and 0.367 µg/mL, respectively. The suggested voltammetric method was successful in detecting torasemide in its pharmaceutical preparation (Torsamolex 20 mg tablets) as well as in spiked urine matrix, demonstrating its suitability for pharmaceutical quality control and potential applications in clinical analysis.