GRANULAR HYDROGELS WITH HIGH DRUG CONTENT FOR CONTROLLED RELEASE SYSTEMS

Abstract

The suspension polymerization of HEMA/PVP compositions in the presence of drugs was studied. The influence of drug type and concentration on polymerization kinetics, particle size, and sorption–desorption properties was determined. A one-step synthesis method was developed for obtaining hydrogel carriers for controlled drug release. It was established that in the presence of drugs (thiotriazoline, omeprazole, isoniazid, amlodipine benzoate), it was possible to carry out suspension polymerization of HEMA compositions with PVP and obtain spherical polymer particles with sizes of 0.2-0.7 mm.