Preparation and evaluation of salbutamol sulphate sublingual tablets

Abstract

Aim of the present work was to prepare and evaluate sublingual tablets of salbutamol sulphate (SAL), for the treatment of asthma and COPD. Conventional SAL tablets available in the market are not suitable where quick onset of action is required. SAL sublingual tablets were prepared by using superdisintegrants like croscarmellose sodium, crospovidone, sodium starch glycolate by direct compression method using 8 mm punch. The prepared tablets were evaluated for postcompression parameters and in vitro drug release studies. Among all formulations F6 formulation was found to be the best as this formulation shown less disintegration time and possessing good tableting properties. An optimized tablet formulation i.e. F6 was found which provided short wetting time of 21 sec, in-vitro disintegration time of 149 sec which facilitates its faster disintegration and higher the drug content of 96.9%, the best in-vitro drug release was found to be in formulation F6 i.e. 97.69% during the end of 30min.