ANTI- HYPERLIPIDEMIC AND ANTI-DIABETIC ACTIVITY OF METHANOLIC EXTRACT OF ANNONA RETICULTA IN ALBINO RATS.

Abstract

The present study was designed to assess the anti - hyperlipidaemic and anti - diabetic Activity of methanolic extract of Annona Reticulta in Albino Rats. The plant extracts of Annona Reticulta were administered orally with maximum dose of 2000 mg/kg bodyweight The biochemical estimations were done by using specific procedures. Cholesterol, Triglycerides, HDL-Cholesterol, SGOT/AST, SGPT/ ALT, Alkaline Phosphatase, Serum Total Proteins and Glucose were determined. The extract also show increase in the glucose tolerance of the rats and decrease in the fasting blood glucoselevel of diabetic rats, showing the hypoglycaemic activity of the plant which is most pronounced in methanol extract. The results of this investigation showed that rats treated with a methanol extract of Annona Reticulta leaves have both anti -hyperlipidaemic and anti-diabetic activity.