FORMULATION AND EVALUATION OF EXTENDED-RELEASE MATRIX TABLETS OF SALBUTAMOL SULPHATE USING NATURAL POLYMERS

Abstract

The present study involves the formulation and evaluation of extended release matrix tablets of Salbutamol Sulphate using natural polymers such as Guar Gum, Locust Bean Gum, and Gum Damar. The primary objective was to develop a sustained release formulation that could maintain therapeutic drug levels over an extended period, thereby reducing dosing frequency and improving patient compliance. A total of nine formulations were prepared using varying concentrations of the selected natural polymers. All formulations were subjected to pre- compression and post-compression evaluations, and the results were found to be within the acceptable limits as per IP standards. Among all, formulation F6 was identified as the optimized batch, as it exhibited the most desirable drug release profile, achieving 99.08% drug release over 12 hours. The study concludes that natural polymers can effectively be used in the formulation of extended release tablets of Salbutamol Sulphate, offering a promising and sustainable alternative to synthetic polymers in controlled drug delivery systems. Keywords: Salbutamol Sulphate, Locust Bean Gum, Guar Gum and Gum Damar