Synthesis of 3,4,5-trisubstituted piperidine via S_N2’ reaction

Abstract

3,4,5-Trisubstituted piperidine-containing compounds displayed a range of biological activities, are potential drug candidates to treatment of Alzheimer’s disease, sexual dysfunctions or obesity, heart and kidney insufficiency. However, the inherent difficulty in obtaining a variety of 3,4,5-trisubstituted piperidines has greatly hindered their systematic medicinal chemistry studies for them. In this paper, we disclose an efficient synthesis of racemic and chiral 3,4,5-trisubstituted piperidines via S_N2’ reaction.