Deposition of DNA Nanostructures on Highly Oriented\nPyrolytic Graphite

Abstract

We\nreport the deposition of DNA origami nanostructures on highly\noriented pyrolytic graphite (HOPG). The DNA origami goes through a\nstructural rearrangement and the DNA base is exposed to interact with\nthe graphite surface. Exposure to ambient air, which is known to result\nin a hydrophilic-to-hydrophobic wetting transition of HOPG, does not\nsignificantly impact the deposition yield or the shape deformation\nof DNA nanostructures. The deposited DNA nanostructures maintain their\nmorphology for at least a week and promote site-selective chemical\nvapor deposition of SiO₂. This process is potentially useful\nfor a range of applications that include but are not limited to nanostructure\nfabrication, sensing, and electronic and surface engineering.