Amphiphilic Near-Infrared Conjugated Polymer for Photothermal\nand Chemo Combination Therapy

Abstract

Amphiphilic conjugated polymer was\ndesigned and utilized as nanocarriers\nwithout further general encapsulation using PEGylated materials for\nphotothermal therapy (PTT) and chemotherapy. These nanocarriers have\nmaximum absorption in ideal phototherapeutic window between 800 and\n850 nm and excellent photothermal conversion efficiency of 76% at\n808 nm. It provides the simultaneous therapy of chemotherapy and PTT\nwith the monitoring of photoacoustic imaging. After combined therapy\nvia tail vein injection, complete remission and no recurrence of tumors\ncan be observed over a course of 20 days, indicating these amphiphilic\nNPs has great potential for NIR photoacoustic imaging-guided photothermal\nand chemo combined therapy.